Publication

Partial list of Publications

Full list at Google Scholar

  1. Nahum, L.; Harel, M.; Touitou, N.; Aon, M.A.; Avivi, M.Y.; Naiman, S.; Rathaus, M.; Gertler, A.A.; Roichman, A.; Lerrer, B.; Ishii, I.; Senderowitz, H.; de Cabo, R.; Geiger, T.; Cohen, H.Y. Characterization of the SIRT6 dependent liver acetylome revealed its role in regulating H2S production, submitted for publication.
  2. Singh Bahia, M.; Kaspi, O.; Touitou, M.; Binayev, I.; Dhail, S.; Yosipof, A.; Senderowitz, H., A comparison between 2D and 3D descriptors in QSAR modeling based on bio-active conformations, Journal of Chemical Information and Modeling, 2021, submitted for publication.
  3. Kaspi, O.; Israelsohn-Azulay, O.; Yigal. Z.; Krmpotić, M.; Guesmia, S.; Bogdanović Radović, I.; Jalkanen, P.; Liski, A.; Räisänen, J.; Girshevitz, O.; Senderowitz, H.; Lab agnostic workflow for forensic applications in car glass classification, Forensic Science International, 2021, submitted for publication.
  4. Frank, Y.; Senderowitz, H., Statistical analysis of sequential motifs at biologically relevant protein-protein interfaces, submitted for publication.
  5. Binyamin, H.; Senderowitz, H., Photovoltaphores: Pharmacophore models for identifying metal-free dyes for dye-sensitized solar cells (DSSCs), NPJ Computational Materials, submitted for publication.
  6. Spiegel, Y.; Senderowitz, H., A comparison between Enrichment Optimization Algorithm (EOA)-based and docking-based virtual screening, International Journal of Molecular Sciences, 2022, 23, 43.
  7. Okalang, U.; Mualem Bar-Ner, B.; Rajan, K.s.; Friedman, N.; Aryal, S.; Egarmina, K.; Hope, R.; Khazanov, N.; Senderowitz, H.; Alon, A.; Fass, D.; Michaeli, S.; The spliced leader RNA silencing (SLS) pathway in Trypanosoma brucei is induced by perturbations of endoplasmic reticulum, Golgi, or mitochondrial proteins factors and functional analysis of SLS inducing kinase, PK3, mBio, 2021, e02602-21.
  8. Pun, M.; Khazanov, N.; Galsurker, O.; Kerem, Z.; Weitman, M.; Senderowitz, H.; Yedidia, I, Phloretin, an Apple Phytoalexin, Affects the Virulence and Fitness of Pectobacterium brasiliense by Inhibiting Interfering with Quorum-Sensing, Frontiers in Plant Sciences, 2021, 12, 671807,
  9. Joshi, R.; Khazanov, N.; Charkowski, A.; Faigenboim, A.; Senderowitz, H.; Yedidia, I., Interkingdom Signaling Interference: The Effect of Plant-Derived Small Molecules on Quorum Sensing in Plant-Pathogenic Bacteria, Annual Review of Phytopathology, 2021, 59, 153-190.
  10. Kaspi, O.; Girshevitz, O.; Senderowitz, H., PIXE Based Machine-Learning (PIXEL) Supported Workflow for Glass Fragments Classification, Talanta, 2021, 234, 122608.
  11. Sabusap, C.M.; Joshi, D.; Simhaev, L.; Oliver, K.A.; Senderowitz, H.; Willigen, M.; Braakman, I.; Rab, A.; Sorscher, E,J.; Hong, J., The CFTR P67L variant reveals a key role for N-terminal lasso helices in channel folding, maturation, and pharmacologic rescue, Journal of Biological Chemistry, 2021, 296, 100598.
  12. Singh Bahia, M.; Khazanov, N.; Zhou, Q.; Yang, Z.; Wang, C.; Hong, J.; Rab, A.; Sorscher, E.; Brouillette, C.; Hunt, J.; Senderowitz, H., Stability Prediction for Mutations in the Cytosolic Domains of CFTR, Journal of Chemical Information and Modeling, 2021, 61, 1762-1777
  13. Rippin, I.; Khazanov, N.; Ben Joseph, S.; Kudinov, T.; Berent, E.; Melisa, S.; Ruiz, A.; Marciano, D.; Levy, L.; Gruzman, A.; Senderowitz, H; Eldar-Finkelman, H. Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site, International Journal of Molecular Sciences, 2020, 21, 8709.
  14. Yosipof, A.; Khalemsky, A.; Gelbard, R.; Senderowitz, H. Dynamic Classification for Materials-Informatics: Mining the Solar Cell Space, Molecular Informatics, 2020, Inf. 2020, 39, 2000173.
  15. Spiegel, J.; Senderowitz, H. Evaluation of QSAR Equations for Virtual Screening, International Journal of Molecular Sciences, 2020, 21, E7828.
  16. Bar Aluma, B.; , I.; Senderowitz, H.; Cohen-Cymberknoh, M.;  Khazanov, N.; Dagan, A.; Bezael, Y.;  Ashkenazi, M.; Keler, S.; Efrati, O.  Phenotypic and molecular characteristics of Cystic Fibrosis patients carrying the I1234V mutation, Respiratory Medicine, 2020, 170, 106027.
  17. Joshi, R.; Khazanov, N.; Burdman, S.; Carmi, N.; Yedidia, I. Senderowitz, H. Direct Binding of Salicylic Acid to PectobacteriumN-Acyl-Homoserine Lactone Synthase, ACS Chemical Biology, 2020, 15, 7, 1883–1891
  18. Touitou, M.; Manetti, F.; Maringolo Ribeiro, C.; Rogerio Pavan,; Scalacci, N.; Zrebna, K.; Begum, N.; Semenya, D.; Gupta, A.; Bhakta, B.; McHugh, T.D.; Senderowitz, H.; Kyriazi, M.; Castagnolo, D., Improving the potency of N-aryl-2,5-dimethylpyrrole antitubercular hybrid derivatives against multidrug-resistant and intracellular mycobacteria, ACS Medicinal Chemistry Letters, 2019, 11, 638-644
  19. Cui, G.; Hong, J.; Chung-Davidson, Y-W.; Xu, X.; Li, J.; Simhaev, L.; Plyler, Z.; Imhoff, B.; Infield, D.; Cottrill, K.; Li, W.; Senderowitz, H.; Sorscher, E.; McCarty, N.; Gaggar, A., An Ancient CFTR Ortholog Informs Molecular Evolution in ABC Transporters, Developmental Cell, 2019, Developmental Cell, 2019, 51, 421-430.e3
  20.  Nassir, M.; Pelletier, J.; Arad, U.; Arguin, G.; Khazanov, N.; Gendron, F-P.; Sévigny, J. Senderowitz, H.; Fischer, B. Structure-activity relationship study of NPP1 inhibitors based on uracil-N1-(methoxy)ethyl-β-phosphate scaffold, European Journal of Medicinal Chemistry, 2019, 184, 111754
  21. Getter, T.; Margalit, R.; Zilber, S.;  Kahremany, S.;  Khazanov, N.;   Levy, L.; Blum, E.; Tamir, T. Y.; Major, B. M.;  Lahav, R.;  Senderowitz, H.;  Bradfield, P.; Imhof, B.;  Alpert, E.; Gruzman, A. Novel inhibitors of leukocyte transendothelial migration. Bioorganic Chemistry 2019, 92, 103250. doi: 10.1016/j.bioorg.2019.103250.
  22. Senderowitz, H.*; Yosipof, A.; Kaspi, O. Application of materials informatics tools to the analysis of combinatorial libraries of all metal-oxides photovoltaic cells Lecture Notes in Computer Science, 2019, 11731, pp. 758–763. *I am the corresponding author on this paper.
  23. Kahremany, S.; Babaev, I.; Gvirtz, R.; Ogen-Stern, N.; Azoulay-Ginsburg, S.; Senderowitz, H.; Cohen, G.; Gruzman, A. Nrf2 Activation by SK-119 Attenuates Oxidative Stress, UVB, and LPS-Induced Damage Skin Pharmacology and Physiology, 2019, 32, 173-181.
  24. Doonan, LM.; Preston, GM.; Guerriero, CJ.; Buck, TM.; Khazanov, N.; Fisher, EA.; Senderowitz, H.; and Brodsky, JL. Hsp104 Facilitates the Endoplasmic Reticulum Associated Degradation of Disease-Associated and Aggregation-Prone Substrates, Protein Science, 2019, 28, 1290-1306.
  25. Senderowitz, H.*; Tropsha, A.* Materials Informatics, Chem. Inf. Model., 2018, 58, 2377-2379 (editorial). *I am the corresponding author on this editorial together with T.A.
  26. Munder A.; Moskovitz ;  Meir A., Kahremany S.;  Cohen G.; Shtriker E.; Levy L.;  Viskind O.;  Lellouche J-P.;  Senderowitz H.;  Chessler S.; Korshin E.;  Rothshtein S.;  Gruzman A. Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells’ proliferation and functions, MedChemComm 2018, 10, 280-293
  27. Kahremany S.; Babaev I.; Hasin P.; Tamir T.; Ben-Zur T.; Cohen G.; Jiang Z.; Weintraub S.; Offen D.; Rahimipour S.; Major B.; Senderowitz H.; Gruzman A. Computer‐Aided Design and Synthesis of 1‐{4‐[(3,4‐Dihydroxybenzylidene)amino]phenyl}‐5‐oxopyrrolidine‐3‐carboxylic Acid as an Nrf2 Enhancer, 2018, 83, 320-333. (Cover page). (Cover page).
  28. Trifonov, L.; Nudelman, V.; Zhenin, M.; Matsree, E.; Afri, M.; Schmerling, B.; Cohen, G.; Jozwiak, K.; Weitman, M.; Korshin, E.; Senderowitz, H.; Shainberg, A.; Hochhauser, E.; Gruzman, A. Structurally Simple, Readily Available Peptidomimetic 1-Benzyl-5-methyl-4-(n-octylamino)pyrimidin-2(1H)-one Exhibited Efficient Cardioprotection in a Myocardial Ischemia (MI) Mouse Model, Journal of Medicinal Chemistry, 2018, 61, 11309-11326.
  29. Kaspi, O.; Yosipof, A.; Senderowitz, H., Visualization of solar cells library space by dimension reduction methods Journal of Chemical Information and Modeling, 2018, 58, 2428-2439.
  30. Chen, X.; Zhu, S.; Zhenin, M.; Xu, W.; Bose, S.J.; Pik-Fan Wong, M.; P. H. Leung, G. Senderowitz, H.; Chen, J-H. A defective flexible loop contributes to the processing and gating defects of the predominant cystic fibrosis–causing mutation, FASEB Journal 2019, 33, 5126-5142.
  31. Atzmon, A.; Herrero, M.; Sharet, R.; Gilad, Y.; Senderowitz, H.; Elroy-Stein, O. Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy, Front Mol Neurosci. 2018, 11:336.
  32. Zhenin, M.; Singh Bahia, M.; Marcou, G.; Varnek, A.; Senderowitz, H.; Horvath, D. Rescoring of Docking Poses under Occam’s Razor – Are there Simpler Solutions? J Comput Aided Mol Des. 2018, 32, 877-888.
  33. Kahremany, S.; Zhenin, M.; Maimoun, D.; Colotti, G.; Arad, M.; Shainberg, A.; Senderowitz, H.; Ruthstein, S.; Gruzman, A. Peptide-based development of PKA activators, New Journal of Chemistry, 2018, 42, 18585 – 18597.
  34. Kakhlon, O.; Ferreira, I.; Solmesky, L.J.; Weil, M.; Khazanov, N.; Senderowitz, H.; Lossos, A.; Alvarez, R.; Yetil, D.; Pampou, S.; Escriba, P.; Yue, W.; Akman, H. Guaiacol as a drug-candidate for treating Adult Polyglucosan Body Disease, 2018, JCI Insight, 2018 3(17). pii: 99694.
  35. Kaspi, O.; Yosipof, A.; Senderowitz, H. PV Analyzer: A Decision Support System for Photovoltaic Solar Cells Libraries, Molecular Informatics, 2018, 37(9-10):e1800067.
  36. Ortuso, F.; . Bagetta, D.; Maruca, A.; Talarico, C.; Bolognesi, M.L.; Haider, ; Borges, F.; Bryant, S.; Langer, T.; Senderowitz, H.; Alcaro, S. The Mu.Ta.Lig. Chemotheca: A community-populated molecular database for multi-target ligands identification and compound-repurposing, Front. Chem. 2018, 6:130.
  37. Mei-Zahav, M.; Stafler, P.; Senderowitz, H.; Bentur, L.; Livnat, ; Shtainberg, M.; Orenstein, N.; Bazak, L.; Prais,  D.; Levine,  H.; Gur, M.; Khazanov,  N.; Simhaev,  L.; Blau, H.; Mussaffi,  H. THE Q359K/T360K MUTATION CAUSES CYSTIC FIBROSIS IN GEORGIAN JEWS, J. Cyst. Fibros. 2018, 17, e41-e45.
  38. Zelikman,a V.; Pelletier, J.; Simhaev, L.; Sela, A.;  Gendron, F-P.; Arguin, G.; Senderowitz, H.; Sevigny, J.;  Fischer, B. Highly Selective and Potent NPP1 Inhibitors Based on Uridine-5’-Phosphorodithioate Analogues, Med. Chem. 2018, 61, 3939-3951.
  39. Wang, C.; Aleksandrov, A.A.; Yang, Z.; Forouhar, F.; Proctor, E.; Kota, P.; An, J.; Kaplan, A.; Khazanov, N.; Boël, G.; Stockwell, B.R; Senderowitz, H.; Dokholyan, N.V.; Riordan, J.R.; Brouillette, C.G; Hunt, J.F. Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator, Biol Chem., 2018, 293, 17685-17704.
  40. Senderowitz, H.*; Tropsha, A.* Materials Informatics, Chem. Inf. Model., 2018, 58, 1313-1314 (editorial). *I am the corresponding author on this editorial together with T.A.
  41. Yang, Z.; Hildebrandt, ; Jiang, F.; Zhou, Q.;  An, J.; Xavier, B.M.; Ding, H.; Khazanov, N.; Senderowitz, H.;  Kappes, J.C.; Brouillette, C.G.; Urbatsch, I.L. Structural stability of purified human CFTR is systematically improved by mutations in nucleotide binding domain 1, Biochim Biophys Acta. 2018, 1860, 1193-1204.
  42. Solmesky, L.J.; Khazanov, N.; Senderowitz, H.; Wang, P.; Minassian, B.; Ferreira, I.M.; Yue, W.; Lossos, A.; Weill, M.; Kakhlon, O. A novel image-based high throughput screening assay discovers therapeutic candidates for adult polyglucosan body disease, Biochemical Journal, 2017, 474, 3403-3420.
  43. Kaspi, O.; Ysipof, A.; Senderowitz, H. Random Sample Consensus (RANSAC) Algorithm for Material-Informatics: Application to Photovoltaic Solar Cells, Journal of Chemoinformatics, 2017, 9, 34.

         This article was selected by Springer-Nature publishing group to be included in the prestigious “Change the World, One Article at a Time initiative”list. See: https://www.springernature.com/gp/researchers/campaigns/change-the-world/chemistry-physics-astronomy-engineering-materials

  1. Simhaev Ischakov, L.; McCarty, N.A.; Ford, R.C.; Senderowitz, H. Molecular Dynamics Flexible Fitting (MDFF) Simulations Identify New Models of Closed State CFTR, Chem. Inf. Model., 2017, 57, 1932-1946.
  2. Munder, A.; Israel, L.; Kahremany, S.; Shabat Binyamini, R.; Zhang, C.; Kolitz-Domb, M.; Viskind, O.; Levine, A.; Senderowitz, H.; Chessler, S.; Lellouche, J-P.; Gruzman, A. Mimicking Neuroligin-2 Functions in β-cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy, ACS Applied Materials & Interfaces, 2017, 9, 1189-1206.
  3. Hildebrandt, E.; Khazanov, N.; Kappes, J.C.; Dai, Q.; Senderowitz, H.; Urbatsch IL. Specific stabilization of CFTR by phosphatidylserine, Biochim Biophys Acta. 2017, 1859, 289-293.
  4. Gilad, Y.; Tuchinski, H.; Ben-David, G.; Minnes, R.; Gancz, A.; Senderowitz, H.; Luboshits, G.;, Firer, M.A.; Gellerman, G. Discovery of potent molecular chimera (CM358) to treat human metastatic melanoma, J. Med. Chem. 2017, 138, 602-615.
  5. Joshi, R.; Khazanov, N.; Senderowitz, H.; Burdman, S.; Lipsky, A.; Yedidia, I. Plant phenolic volatiles inhibit quorum sensing in Pectobacteria and reduce their virulence by potential binding to ExpI and ExpR proteins, Scientific Reports, 2016, 6, 38126.
  6. Yosipof, A.; Kaspi, O.; Majhi, K,; Senderowitz, H. Visualization Based Data Mining for Comparison Between Two Solar Cell Libraries, Molecular Informatics, 2016, 35, 622-628.
  7. Yosipof, A.; Shimanovich, K.; Senderowitz, H. Materials Informatics: Statistical Modeling in Material Science, Molecular Informatics, 2016, 35, 568-579.

This article was one of the top downloaded articles in 2017.

  1. Cui, G.; Khazanov, N.; Stauffer, B.B.; Infield, d.T.; Imhoff, B.R., Senderowitz, H.; McCarty, N.A. Potentiators exert distinct effects on human, murine, and Xenopus CFTR, Am J Physiol Lung Cell Mol Physiol. 2016, 311, L192-207.
  2. Gilad, Y.; Noy, E.; Senderowitz, H.; Albeck, A.; Firer, M.A.; Gellerman, G. Synthesis, biological studies and molecular dynamics of new anticancer RGD-based peptide conjugates for targeted drug delivery, Bioorganic and Medicinal Chemistry, 2016 24, 294-303.
  3. Gilad, Y.; Noy, E.; Senderowitz, H.; Albeck, A.; Firer, M.A.; Gellerman, G. Dual-drug RGD conjugates provide enhanced cytotoxicity to melanoma and non-small lung cancer cells, Peptide Science, 2015, 106, 160-171.
  4. Khazanov, N.; Iline-Vul, T.; Noy, E.; Goobes, G.; Senderowitz, H. Design of Compact Biomimetic Cellulose Binding Peptides as Carriers for Cellulose Catalytic Degradation, Phys. Chem. B. 2016, 120, 309-19.
  5. Nahum O. E.; Yosipof, A. Senderowitz, H. A Multi-Objective Genetic Algorithm for Outlier Removal, Chem. Inf. Model., 2015, 55, 2507-2518.
  6. Zhenin, M.; Noy, E.; Senderowitz, H. REMD Simulations Reveal the Dynamic Profile and Mechanism of Action of Deleterious, Rescuing and Stabilizing Perturbations to NBD1 from CFTR, Chem. Inf. Model., 2015, 55, 2349–2364.
  7. Avgy-David, H.; Senderowitz, H. Toward Focusing Conformational Ensembles on Bioactive Conformations: A Molecular Mechanics/Quantum Mechanics Study, Chem. Inf. Model. 2015, 55, 2154–2167.
  8. Gilad, Y; Nadassy Katalin; Senderowitz, H. A reliable computational workflow for the selection of optimal screening libraries, Cheminformatics, 2015, Dec 11;7:61. doi: 10.1186/s13321-015-0108-0. eCollection 2015.
  9. Yosipof, A.; Nahum, O. E.; Anderson, A. Y.; Barad, H.; Zaban, A.; Senderowitz, H. Data Mining and Machine Learning Tools for Combinatorial Material Science of All-Oxide Photovoltaic Cells, Molecular Informatics, 2015, 34, 367–379.
  10. Getter, T.; Zaks, I,; Barhum, Y; Ben-Zur, T.; Böselt, S.; Gregoire, S.; Viskind, O.; Shani, T.; Gottlieb, H.; Green, O.; Shubely, M.; Senderowitz, H.;  Israelson, A.; Kwon, I.; Petri, S.; Offen, D.; Gruzman, A. A Chemical Chaperone-Based Drug Candidate is Effective in a Mouse Model of Amyotrophic Lateral Sclerosis (ALS), ChemMedChem, 2015, 10, 850-61.
  11. Momic, T.; Katzehendler, J.; Shai, E.; Varon, D.; Noy, E.; Senderowitz, H.; Eble, J. A.;  Marcinkiewicz, C.; Lazarovici, P. Vipegitide: a folded peptidomimetic partial antagonist of α2β1 integrin with antiplatelet aggregation activity, Drug Design, Development and Therapy, 2015, 9, 291-304.
  12. Yosipof, A.; Senderowitz, H. k-Nearest Neighbors optimization based outlier removal. Comput. Chem. 2015, 36, 493-506.
  13. Kahremany, ; Livne, A.; Gruzman, A.; Senderowitz, H.*; Sasson S.* Activation of PPARδ: from computer modeling to biological effects, Br. J. Pharmacol. 2015 172, 754-70. *I am the corresponding author on this paper together with S.S.
  14. Momic, T.; Katzehendler, J.;, Lahiani, A.; Cohen, G.; Noy, E.; Senderowitz, H.; Eble, J. A.; Marcinkiewicz, C.; Lazarovici, P. Vimocin and vidapin, cyclic KTS peptides, are dual antagonists of α1β1/α2β1 integrins with antiangiogenic activity, J Pharmacol Exp Ther. 2014, 350 506-19.
  15. Yosipof, A.; Senderowitz, H. Optimization of molecular representativeness. J Chem. Inf. Model. 2014, 54 1567-77.
  16. Nadel, Y.; Lecka, J.; Gliad, Y.; Ben-David, G.; Förster, D.; Reiser, G.; Kenigsberg, S.; Camden, J.; Weisman, G.A.; Sendrowitz, H.*; Sévigny, J.*; Fischer, B.* Highly Potent and Selective Ectonucleotide Pyrophosphatase/Phosphodiesterase I Inhibitors Based on an Adenosine 5′-(α or γ)- Thio-(α,β- or β,γ)-methylenetriphosphate Scaffold, Med. Chem. 2014 57, 4677-91. *I am the corresponding author on this paper together with S.J. and F.B.
  17. Gillerman, I.; Lecka. J.; Simhaev, L.; Munkonda, M.N.; Fausther, M.; Martín-Satué, M.; Senderowitz, H.*; Sévigny, J.*; Fischer, B.* 2-Hexylthio-β,γ-CH2-ATP is an effective and selective NTPDase2 inhibitor, J Med Chem. 2014, 57 5919-34. *I am the corresponding author on this paper together with S.J. and F.B.
  18. Gilad, Y.; Senderowitz, H. Docking Studies on DNA Intercelators, Chem. Inf. Model. 2014, 54, 96-107.
  19. Lecka, J.; Ben-Daviv, G.; Simhaev, L.; Eliahu, S.; Oscar, J.; Luyindula, P.; Pelletier, J.; Fischer, B.; Senderowitz, H.; Sevigny, Nonhydrolyzable ATP Analogues as Selective Inhibitors of Human NPP1: A Combined Computational/Experimental Study, Med. Chem. 2013, 56, 8308-20.
  20. Meltzer-Mats, E.; Babai-Shani, G.; Pasternak, L.; Uritsky, N.; Getter, T.; Viskind, O.; Eckel, J.; Cerasi, E.;Senderowitz, H.; Sasson, S.; Gruzman, A. Synthesis and Mechanism of Hypoglycemic Activity of Benzothiazole Derivatives, J Med Chem. 2013, 56, 5335-50.
  21. Hudson, R.; Chong, A.; Protasevich, I.I, Vernon, R.; Noy, E.; Bihler, H.; Li An, J.; Kalid, O.; Sela-Culang, I.; Mense, M.; Senderowitz, H.; Brouillette, C,; Forman-Kay, J.D. Conformational changes relevant to channel activity and folding within the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator, J Biol Chem. 2012, 287, 28480-94.
  22. Noy, E.; Senderowitz, H. Combating cystic fibrosis: in search for CF transmembrane conductance regulator (CFTR) modulators, ChemMedChem 2011, 6, 243-51 (invited).
  23. Noy, E.; Senderowitz, H. Molecular simulations for the evaluation of binding free energies in lead optimization, Drug Development Research, 2011, 72, 36-44 (invited).
  24. Stempler, S.; Levy-Sakin, M.; Frydman-Marom, A.; Amir, Y.; Scherzer-Attali, R.; Buzhansky, L.; Gazit ; Senderowitz, H. Quantitative Structure-Activity Relationship Analysis of β-Amyloid Aggregation Inhibitors, J. Comput. Aided. Mol. Design 2011, 25, 135-44.
  25. Musafia, B.; Senderowitz, H. Biasing conformational ensembles towards bioactive-like conformers for ligand-based drug design, Expert Opinion on Drug Discovery, 2010, 5, 943-59 (invited).
  26. Thibodeau, P.H.; Richardson III, J.M.; Wang, W.; Millen, L.; Watson, J.; Mendoza, J.; Du, K.; Fischman, S.; Senderowitz, H.; Lukacs, G.; Kirk, K.; Thomas, P.J. The cystic fibrosis-causing mutation deltaF508 affects multiple steps in cystic fibrosis transmembrane conductance regulator biogenesis, JBC, 2010 285, 35825-35.
  27. Kalid, O.; Fischman, S.; Mense, M.; Shitrit, A.; Bihler, H.; Ben-Zeev, E.; Schutz, N.; Pedemonte, N.; Thomas, P.J.; Bridges, R.J.; Wetmore, D.R.; Marantz, Y.; Senderowitz, H. Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening, Comput. Aided. Mol. Design, 2010, 24, 971-91.
  28. Sela, I.; Golan, G.; Strajbl, M.; Rivenzon-Segal, D.; Bar-Haim, S.; Bloch, I.; Inbal, B.; Shitrit, A.; Ben-Zeev, E.; Fichman, M.; Markus, Y.; Marantz, Y.; Senderowitz, H.; Kalid, O. G protein coupled receptors -in silico drug discovery and design, Curr Top Med Chem. 2010, 10, 638-56.
  29. Musafia, B.; Senderowitz, H. Bioactive conformational biasing: A new method for focusing conformational ensembles on bioactive conformers Chem. Inf. Model. 2009, 49, 2469-80.
  30. Senderowitz, H.; Marantz Y. G protein-coupled receptors: Target-based in silico screening Current Pharmaceutical Design, 2009, 15, 4049-68 (invited).
  31. Bar-Haim, S.; Aharon, A.; Ben-Moshe, T.; Marantz, Y.; Senderowitz, H. SeleX-CS: A new consensus scoring algorithm for hit discovery and lead optimization Chem. Inf. Model., 2009, 49, 623-33.
  32. Litman, P.; Ohne, O.; Ben-Yaakov, S.; Shemesh-Darvis, L.; Yechezkel, T.; Salitra, Y.; Rubnov, S.; Cohen, I.; Senderowitz, H.; Kidron, D.; Livnah, O.; Levitzki, A.; Livnah, N. A novel substrate mimetic inhibitor of PKB/Akt inhibits prostate cancer tumor growth in mice by blocking the PKB pathway Biochemistry, 2007, 46, 4716-4724.
  33. Hess, S.; Ovadia, O.; Shalev, D.E.; Senderowitz, H.; Qadri, B.; Yechezkel, T.; Salitra, Y.; Sheynis, T.; Jelinek, R.; Gilon, H.; Hoffman, A. Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability Med. Chem., 2007, 50, 6201-6211.
  34. Rayan, A.; Senderowitz, H.; Goldblum, A. Exploring the conformational space of cyclic peptides by a stochastic search method Mol. Graph. Model., 2004, 22, 319-333.
  35. Akavia, A.; Senderowitz, H.; Lerner, A.; Shamir, R. Designing multi route synthesis in combinatorial chemistry Comb. Chem., 2004, 6, 540-548.
  36. Senderowitz, H.; Rosenfeld R. Design of structural combinatorial libraries that mimic biological motif Journal of Receptor and Signal Transduction Research, 2001, 21, 489-508 (invited).
  37. Falb, E.; Salitra, Y.; Yechezkel, T.; Bracha, M.; Litman, P.; Olender, R.; Rosenfeld, R.; Senderowitz, H.; Jiang, S.; Goodman, M. A Bicyclic and Hsst2 selective somatostatin analog: Design, synthesis conformational analysis and binding Bioorganic & Medicinal Chemistry, 2001, 9, 3255-3264.
  38. Perez S.; Imberty, A.; Engelsen, S.B.; Gruza, J.; Mazeau, K.; Jimenez-Barbero, J.; Poveda, A.; Espinosa, J.; van Eyck, B.P.; Johnson, G.; French, A.D.; Kouwijzer, M.L.C.E.; Rootenius, P.D.J.; Bernardi, A.; Raimondi, L.; Senderowitz, H.; Durier, V.; Vergoten, G.; Rasmussen, K. A comparison and chemometric analysis of several molecular mechanics force fields and parameter sets applied to carbohydrate Carbohydrate Res., 1998, 314, 141-155.
  39. Senderowitz, H.; Still, W.C. Sampling the potential energy surface of a Glycyl-Glycine peptide: Comparison of Metropolis Monte Carlo and stochastic dynamics Comput. Chem., 1998, 19, 1294-1299.
  40. Senderowitz, H.; Still, W.C. MC(JBW): Simple but smart Monte Carlo algorithm for free energy simulations of multiconformational molecules Comput. Chem., 1998, 19, 1736-1745.
  41. Senderowitz, H.; McDonald, D.Q.; Still W.C. A practical method for calculating relative free energies of binding. Chiral recognition of peptidic ammonium ions by synthetic ionophores Org. Chem., 1997, 62, 9123-9127.
  42. Diedrich, M.K.; Klärner, F-G.; Beno, B.R.; Houk, K.N.; Senderowitz, H.; Still, W.C. Experimental determination of the activation parameters and stereoselectivities of the intramolecular Diels-Alder reactions of 1,3,8-Nonatriene, 1,3,9-Decatriene and 1,3,10-Undecatriene and transition state modeling with the Monte Carlo-Jumping Between Wells/molecular dynamics method Am. Chem. Soc., 1997, 119, 10255-10259.
  43. Senderowitz, H.; Still, W.C. Anomeric free energy of D-mannose in water: A comparison of free energy perturbation, potential of mean force and MC(JBW)/SD simulations Phys. Chem. B, 1997, 101, 1409-1412.
  44. Senderowitz, H.; Still, W.C. A quantum mechanically derived all atom force field for pyranose oligosaccharides. AMBER* parameters and free energy simulations Org. Chem., 1997, 62, 1427-1438.
  45. Senderowitz, H.; Fuchs, B. Steric and stereoelectronic effects in saturated heterocycles. 1. Small molecular fragment constituents. Theory vs. experiment Journal of Molecular Structure (THEOCHEM), 1997, 395, 123-155.
  46. Golender, L.; Senderowitz, H.; Fuchs, B. Relative stabilities and conformational ring inversion potential in heterodecalins decalin systems and stereoelectronic implications Journal of Molecular Structure (THEOCHEM), 1996, 370, 221-236.
  47. Senderowitz, H.; Parish, C.; Still. W.C. Carbohydrates: United atom AMBER* parameterization of pyranoses and simulations yielding anomeric free energies Am. Chem. Soc., 1996, 118, 2078-2086.
  48. Senderowitz, H.; Guarnieri, F.; Still, W.C. A smart Monte Carlo technique for free energy simulations of multiconformational molecules. Direct calculation of the conformational populations of organic molecules Am. Chem. Soc., 1995, 117, 8211-8219.
  49. Senderowitz, H.; Linden, A.; Golender, L.; Abramson, S.; Fuchs, B. Structure and conformation of heterocycles. 25. New supramolecular host system. 1. A structural and conformational study of the 1,3,5,7-Tetraoxadecalin core system Tetrahedron, 1994, 50, 9691-9706.
  50. Senderowitz, H.; Golender, L.; Fuchs, B. New supramolecular host system. 2. 1,3,5,7-Tetraoxadecalin, 1,2-Dimethoxymethane and the gauche effect reappraised. Theory vs. experiment Tetrahedron, 1994, 50, 9707-9728.
  51. Senderowitz, H.; Aped, P.; Fuchs, B. computations of O-C-F and N-C-F systems: Ab initio calculations and a MM2 parameterization study. Theory vs. experiment Tetrahedron, 1993, 49, 3879-3898.
  52. Senderowitz, H.; Aped, P.; Fuchs, B. Modified MM2 scheme for computation of O-C-N containing systems Comput. Chem., 1993, 14, 944-960.
  53. Aped, P.; Fuchs, B.; Goldberg, I.; Senderowitz, H.; Tartakovsky, E.; Weiman, S. Structure and conformation of heterocycles. 21. Probing the anomeric effect in orthoesters. Structure, conformation and dynamic behavior of a unique Orthooxalate: 2,5,7,10,11,14-Hexaoxa[4.4.4]Propellane Am. Chem. Soc., 1992, 114, 5585-5590.
  54. Senderowitz, H.; Aped, P.; Fuchs, B. Computation of N-C-N systems: Theory vs. experiment Tetrahedron, 1992, 48, 1131-1144.
  55. Ben-Horin, N.; Senderowitz, H.; Kaldor, U.; Even, U.; Jortner, J. An electrostatic model for the energetics of large heteroclusters cations Phys. Chem., 1992, 96, 1569-1575.
  56. Borremans, F.; Anteunis, M.; Aped, P.; Goldberg, I.; Senderowitz, H.; Tartakovsky, E.; Fuchs, B. Structure, conformation and stereoelectronics of 9,10-Annelated-1,4,5,8-tetraoxadecalins: A multidisciplinary probe Tetrahedron, 1991, 47, 5781-5796.
  57. Senderowitz, H.; Aped, P.; Fuchs, B. Structure and conformation of heterocycles. 19. Probing the anomeric effect in O-C-N systems: Theory vs. experiment. MO-ab initio calculations and a structural statistical analysis Chim. Acta, 1990, 73, 2113-2128.
  58. Schleifer, L.; Senderowitz, H.; Aped, P.; Tartakovsky, E.; Fuchs, B. Structure and conformation of heterocycles. 16. Diagnostic structural criteria for the anomeric effect in carbohydrate systems and inferences of general significance on their scope and limitations Carbohydrate Res., 1990, 206, 21-39.
  59. Senderowitz, H.; Schleifer, L.; Aped, P.; Fuchs, B. Conformational energy and entropy differences of the t-butoxy group and implications in stereochemistry and stereoelectronics Tetrahedron Lett., 1989, 30, 6765-6768.